Another piece of cancer puzzle falls into place

first_imgAn international team of researchers has created a genome-scale map of 26 cancers, revealing more than 100 genomic sites where DNA from tumors is either missing or abnormally duplicated compared to normal tissues. The study, the largest of its kind, finds that most of these genetic abnormalities are not unique to one form of cancer, but are shared across multiple cancers.“Our findings show that many genome alterations are universal across different cancers. Although this has been known for some types of changes, the degree to which so many alterations are shared was pretty surprising to us,” said senior author Matthew Meyerson, a Harvard Medical School professor of pathology at the Dana-Farber Cancer Institute and senior associate member of the Broad Institute of Harvard and MIT. “It suggests that, in the future, a driving force behind cancer treatment will be common genomic alterations, rather than tumors’ tissue of origin.” The work appears in yesterday’s edition of the journal Nature.Cancers now are characterized largely by their symptoms: the organs in the body in which they first arise and the appearance of tumor cells under a microscope. Although this information is valuable, it fails to highlight cancers’ molecular underpinnings, which could be used in laboratories to discover new, more effective cancer therapies and in the clinic to improve diagnosis and treatment. A goal ofmodern biomedical research is to fill this knowledge gap and describe all cancers based on what drives them — that is, the genetic aberrations that initiate and maintain tumor growth.In 2004, a scientific team led by researchers at the Dana-Farber and the Broad Institute launched a project to map systematically the genetic changes across different cancers. They focused on a particular type of DNA change in which segments of a tumor’s genome are present in abnormal copies. Instead of the usual two copies, tumors often carry several copies of one piece of DNA (an “amplification”) or may lack it altogether (a “deletion”). These genetic abnormalities are known as somatic copy-number alterations, or SCNAs.Like other types of DNA mutations that litter the genomes of tumor cells, most SCNAs do not necessarily play a meaningful role in cancer growth. But the ones that do serve as important signposts, pointing to the specific genes contained within them that help to promote and maintain cancers. The challenge lies in distinguishing these so-called drivers from their less influential counterparts.As the foundation for their analysis, the scientists collected more than 2,500 cancer specimens representing more than two dozen cancer types, including lung, prostate, breast, ovarian, colon, esophageal, liver, brain, and blood cancers.“Studies like this require a large and diverse group of tumor specimens,” said first author Rameen Beroukhim, an assistant professor of medical oncology at Dana-Farber Cancer Institute and a researcher at the Broad Institute. “We are deeply grateful to our collaborators and to their patients, who generously shared samples with us.”Using powerful genomic “chip” technologies, the researchers analyzed DNA from these samples, and combined their data with publicly available data from 600 more tumor samples to assemble a detailed catalogue of the SCNAs present in multiple tumor types. They found that the most common SCNAs tend to come in two sizes: relatively long, about the length of an entire chromosome or a single chromosome arm, and short, with an average size of about 1.8 million genetic letters, or 0.03 percent of the entire human genome.The researchers focused their attention on the short, or focal, SCNAs which, due to their relatively compact size, can ease the task of pinpointing important cancer genes.“Until recently, the analytic methods needed to support this kind of analysis were not available,” said first author Craig Mermel, a physician and Ph.D. student working in Meyerson’s laboratory and at the Broad Institute. “New advances by our group as well as many others have now made it feasible to systematically map genomic changes across thousands of samples and at high resolution.”Of the 150 or so focal SCNAs they identified, Meyerson and his colleagues noticed that the majority did not coincide with genes already known to be amplified or deleted in cancer. Looking more closely at the genes that normally reside in these regions, the researchers found an enrichment of genes with important biological functions in cancer, such as cell death, or “apoptosis.”This analysis helped to shed light on two genes, MCL1 and BCL2L1. Cancer cells with amplifications of these genes appear to rely on the genes’ activity for survival, suggesting important roles in maintaining tumor growth.Perhaps most importantly, looking across the data for the various cancers, it became clear that most focal SCNAs are not unique to just one type of cancer, but are shared among multiple tumor types. In an analysis of 17 cancer types, the researchers found that most amplifications and deletions are present in more than one type. That suggests the genetic mechanisms that underlie these tumors are shared among them, and could someday lead to common strategies for treating them.“These data signify an important resource for cancer gene discovery, but they’re only a first step,” said Meyerson. “With the ongoing revolution in genome technology, it will become possible to decode the genomes of thousands of cancers to reveal every genomic change.”The Nature study was supported by the National Institutes of Health, the Doris Duke Charitable Foundation, the Sarah Thomas Monopoli Lung Cancer Research Fund, the Seaman Corporation Fund for Lung Cancer Research, and the Lucas Foundation.last_img read more

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Kootenay sniper Shea Weighill earns provincial accolades

first_imgShea Weighill continues to be one of the bright lights on the Kootenay Wildcats Female Hockey team. Earlier this week the Nakusp star was recognized by B.C. Hockey as the Female Midget AAA League’s player of the month for December. Weighill, 17, has been a big part of the Cats success this season scoring three times during the recent month to pace the Kootenay offence. Weighill was also the winner of the shoot-out competition during this season’s All Star game at the Langley Events Centre. The 5’4”, 145-pound forward currently leads the Wildcats in scoring with seven goals and three assists. In three seasons of Female Midget hockey Weighill has accumulated 40 points on 22 goals and 18 assists. Kootenay is tied fourth in league standings, two points behind third-place Vancouver Fusion. The Wildcats resume action Saturday in Kelowna against the second place Thompson-OkanaganRockets at the Kelowna Memorial Arena. Other players in the running include Brianna Keats of the Fraser Valley Phantom, Kianna Karolyi of Thompson-Okanagan and Carley Bursey of Prince George Cougars. The Female Midget AAA League was created in 2007 to help provide elite female hockey players in the province the opportunity to play at a higher level. [email protected]last_img read more

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MelodySusie® Blonde Long Curly Wigs – Always from

first_imgThe wig arrived in a pretty looking box, introduced really properly. . In the box you get the wig by itself, a attractive comb and also a extremely valuable hairnet. . Both of those myself and my daughter have thick darkish hair and the internet is really fairly awesome as it does really maintain your hair all in place and flat so that the wig can suit on greater, furthermore we discovered the wager truly looks to grip the wig inside too so retains it on your head better as nicely. The wig feels pretty and comfortable to contact, not itchy at all. And its rather uncomplicated to brush and modify into condition conveniently. This wig has attractive pretty natural searching waves in it. We are equally quite satisfied with it. I have received this merchandise at a decreased level and have made a decision to evaluate it in my individual terms with my full straightforward impression. I like to assistance other purchasers who rely on assessments when it will come to determining no matter if to make purchases so if i feel an product is bad i will be trustworthy and say so, but if i adore it i will fortunately say that much too.But soon after manipulating it and darkening the roots marginally i am in appreciate. The colour is amazing it is a little more. Wasn’t certain about this when it arrived, the color is so vivid. But following manipulating it and darkening the roots slightly i am in adore. The color is amazing it’s a small extra orangey crimson than the photo demonstrates but it really is really flattering. The far more it is really worn the much better it seems, as the shine fades and the curls loosen it appears like natural hair that has been coloured. I my sister needs me to get an additional one particular for her. For the selling price the excellent is truly great. Shipping and delivery is brief and really like the little box, comb and cap combo it will come with.Beautifully packaged with a beautiful wig inside of – incredibly happy.A fun wig for partiesBeautiful long blonde hairit would have been fine.Amazing, LOVE THISAbsolutely beautiful wigIt’s perfect for cosplays and costume I have purchased wigs from this seller formerly – this wig (blonde) is beautiful in colour and the top quality is fab, but the glow on this wig lets it down. If it failed to have a shiny wig seem to it, it would have been wonderful.Actually it is so very good i won’t be able to praise it adequate. Highly recommendevery wig i have obtained from melodysusie has been excellent. Excellent items at a great cost. Was even better than i envisioned.It truly is ideal for cosplays and costume. It is ideal for cosplays and costume. The high-quality is really superior for the price tag but it does have some shine to it. But i think i will resolve that with some powder. I would not precisely propose it for every day use however. All on all i like the packaging and i am really glad with the buy.Extremely happy with my buy from melodysusie, they’re generally significant excellent and totally best. I extremely recommend them, image connected of how the blonde wig appears to be.This product or service was sent to me for test and analysis needs. Out of the choices on this solution webpage, this review relates to the design fp718 light-weight blonde curly. The wig is effectively made with an adjustable cap that stays in place when tightened to in good shape your head. In the box there is also a large-mesh hairnet to have your own hair (invaluable for me simply because i by now have long hair), a expert comb to limit destruction to the artificial hair, and a hairnet to retail store the wig neatly. Tips for washing are printed on the box, but one can very easily obtain much more information on the internet. I located that using a tiny distinct conditioner was essential to contain the static that develops if you comb the wig, as one particular does. The primary issue is to stay away from warmth, and mainly this style of wig is pre-styled and created to keep its form and curl. If you wash it in chilly water, the unique waves will be preserved. The other factor to stay clear of is hair shampoo and conditioner which would make it greasy and hefty.This wig arrived in a beautiful little white and lilac box which included the wig alone, a wig web, wig comb and handy instructions on how to cleanse and treatment for the wig. The color is quite related to the color that is in the shots, it feels definitely tender and the curls are bouncy. In general the wig appears sensible and feels light even though on. Even so, i had some complications styling the fringe/bangs and the prime portion of the wig seemed to search a bit far too round, but i managed to take care of this by just clipping the fringe element again. I wore this as portion of a halloween costume and it was snug to use all over the night time. It from time to time got itchy but it was bearable. I very recommend this wig for how real looking it appears to be like and for the comfort. Excellent for extravagant costume functions or just day to day use.The melodysusie blonde long curly wig arrived very quickly and packed well. The deal is made up of- 1x melodysusie wig- 1x wig cap- 1x wig combi have been thrilled with the remarkable high quality of this wig. It can be so comfortable to contact when you just take it out of its packaging and netting and it can be well introduced. It is designed of tender thick lustrous kanekalon and it genuinely appears to be like like a natural authentic hair. This wig is as the photo reveals and is a pleasure to dress in and i get masses of compliments on it from household and buddies. It can take 5 seconds to set on and you never even have to brush it. The wig is also uncomplicated to clean. The vendor endorses that the wig shall be cleaned every single fifteen-30 times normally. When i put on a wig, i often like to incorporate an accessory or two to it just to jazz it up – like a hairband, flower or a clasp.My melodysusie® blonde long curly wigs – natural, fluffy and sexy wigs with free wig cap and wig comb (light blonde) arrived the future working day employing amazon primary and was effectively packaged – priced at £14. ninety nine at time of reviewing it features excellent value way too. My natural hair is dim brown/practically black so even though i have normally wanted to be blonde it hasn’t been an selection as i would constantly be touching up my roots – so this wig is the perfect substitute .I adore the design and style of the wig it comes with whole washing directions, hair web, comb – do not use heated rollers or curling tongs on this wig – it can however be minimize to a additional wished-for design by a an skilled hairdresser should really you so desire to. I put it on and it felt relaxed on and i wore it out for a finish different glimpse. The wig stayed on and the model remained. The wig should be cleaned concerning 15-30 times preferably and it arrives with a revenue back again assurance. * disclaimer i gained this item free/or at a decreased expense in return for an sincere review and this in no way affected the integrity of my evaluation. You should do not rate my assessment as unhelpful for this purpose.This is a actually gorgeous long blonde wig, i purchased fp718 light-weight blonde, which is a light, natural blonde color. The fibres are delicate, shiny and glimpse and sense natural. The strands are pretty long, and the hair duration virtually reaches my waistline (a tall adult). The wig has acquired a great excess weight to it, like perfectly-nourished long hair, and sits very the natural way all around the shoulders and down the again. It is a little wavy in direction of the ends. The fringe is properly formed – its length spans down about 50 % the face when worn down, though it can be worn to one particular side. The measurement of the wig can be modified to the required head dimension working with the elastic adjusters with hooks on the inside of. It would suit very much any adult sized head. The wig is quick to preserve.Lovely wigso trendy appears to be so realwife appreciate these we have brown and blonde nowdefinitely likely to acquire other individuals shorter stylesyou get it all below. Comb , cap and the wigs can be slash and styled tooget for female who like to have many looksthis merchandise was sent to me to do a unbiased overview (lower price/free)fantastic for roll enjoy as well wink wink.last_img read more

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Jeremy Goyings, June 13

first_imgShare Facebook Twitter Google + LinkedIn Pinterest It is a nice morning, but it would be a lot nicer if we had a little bit of rain. We are in dire need here of some rain pretty quick. A week ago Saturday we had seven tenths and that didn’t even fill the cracks. We were back in the field putting on anhydrous the next day. It was amazing how dry it was after almost an inch of rain. It had been close to two weeks since a major rain before that.We were just walking the wheat and it came through flowering very nicely. We don’t have any visible disease pressure yet. Time will tell when the combine gets to roll. I think we’ll be at least a week or so ahead. We’ll probably be rolling here in two weeks, if not a little before that. Hopefully we get some rain on Wednesday or Thursday and the rain may help finish it off. If you can believe it we are at 100% chance of rain on Wednesday.Everything is up and going and looking pretty good. In hindsight that stuff we planted on April 27 struggled and I replanted some of those beans. They are popped out of the ground but they need a rain or they are going to dry up.On May 31 and June 1 I did all of the replanting. That is probably my least favorite job to do on the farm. Out of the 400 acres I planted early, I redid about 200 acres. They are non-GMO beans and they yield well for us, but they are not as strong popping out of the ground.We finished up sidedressing on Friday. Everything went on well and the corn is looking pretty good. There is a stand everywhere but some of that early stuff does not have a picket fence stand.last_img read more

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Analysts: Amazon About To Get Serious Competition In The Cloud

first_imgAmazon Web Services (AWS) clearly leads the Infrastructure-as-a-Service (IaaS) market and by some distance. But whether developers should follow AWS largely depends on where they want to go, according to new research from Forrester. Not only does this require a choice between Platform-as-a-Service (PaaS) offerings and IaaS, but there’s also real IaaS competition brewing for AWS from Microsoft and Google.The easy choice of “AWS or more AWS?” may be about to disappear.Why Amazon Wins In CloudBut let’s not get ahead of ourselves. For now, AWS offers five times the utilized compute capacity of each of its other 14 top competitors—combined. That’s a big lead, and stems from AWS’ quasi-religious focus on its customers’ needs, as Gartner’s Lydia Leong offers. Couple this with a “willing[ness] to invest massively in engineering” and “iterate at shocking speed,” and you get a sense both for why Amazon has been so successful, and why it’s so hard to catch up.Small wonder, then, that Forrester’s developer survey finds that AWS has a clear lead, with 62% of developers surveyed indicated that they’ve implemented AWS already, with another 23% planning to do so. The numbers for Microsoft and Google are not nearly so good: Tags:#cloud computing#developers#Forrester#Gartner#IaaS#paas#RDBMS Cloud Hosting for WordPress: Why Everyone is Mo… Related Posts Serverless Backups: Viable Data Protection for … This could be a function of enterprises turning to a trusted database provider for their RDBMS needs. It could just be a short-term blip as enterprises explore other cloud database offerings, an area in which AWS excels and Google is growing. Or it could just be, as Hammond suggests, that one-cloud-size-does-not-fit-all.In such a world, according to Leong, different cloud vendors bring different strengths, and each of the two primary challengers has pockets as deep or deeper than Amazon. Take Microsoft, for example. “Microsoft has brand, deep customer relationships, deep technology entrenchment, and a useful story about how all of those pieces are going to fit together, along with a huge army of engineers, and a ton of money and the willingness to spend wherever it gains them a competitive advantage.” And what about Google? “Google has brand, an outstanding engineering team, and unrivaled expertise at operating at scale.”Lots To Play For In CloudIn short, we’re a long way from deciding an absolute winner in cloud computing. In part this is because we’re still in the early days of adoption, and in part it’s because, as Hammond insists, developers are increasingly buying the best tool for a particular job. Amazon has established a clear leadership position, but it isn’t the only cloud vendor with a strong cloud story. Microsoft still needs to overcome its Microsoft-centric approach to the cloud (and everything else), and Google still needs to figure out how to operate like a business that enterprises can understand and buy from, but these are solvable problems.One thing is clear: as these problems are solved, an interesting but not particularly competitive cloud market will become even more interesting, and much more competitive.Image courtesy REUTERS/Shannon Stapleton.center_img Top Reasons to Go With Managed WordPress Hosting Amazon has been looking to extend this lead by making its IaaS offerings more enterprise friendly. Importantly, Amazon isn’t building out a separate enterprise cloud, but instead is meshing enterprise features with its public cloud, a strategy that jibes with Leong’s belief that “customers actively do not want two different clouds, since nobody really wants to shift between different clouds as you go through an application’s lifecycle, or for different tiers of an app, some of which might need greater infrastructure resilience and guaranteed performance.”And lest anyone think AWS simply serves the rinky-dink individual developer with a dev/test workload, Leong stresses that its customers are decidedly “traditional enterprises of the Global 2000 variety (including some of the largest companies in the world),” in addition to the mid-market, “projected spend levels… increasing dramatically… use cases [that] are extremely broad,…[with] workloads [that] increasingly have sensitive data and regulatory compliance concerns.”So, game over, Amazon wins?Cloud Competitors RisingNot so fast. If ever there were a market with deep-pocketed competitors who can financially afford to catch up and compete, this is it. And, as Forrester’s Jeffrey Hammond argues, “We’re moving away from distinct leaders in a single market segment, like IaaS or PaaS, and toward a model that mirrors a traditional buying pattern, where app development professionals choose between best of breed services (e.g., compute, storage, RDBMS, messaging, CRM) or integrated data-centers of services (AWS, Microsoft Azure, Google Cloud Platform, Salesforce/Heroku/Database.com).”In this world where buyers focus on best-of-breed, AWS doesn’t necessarily always have the upper hand.For example, Microsoft already competes quite well with AWS when it comes to developers using a cloud relational database (RDBMS), as Forrester’s survey finds: Matt Asay How Intelligent Data Addresses the Chasm in Cloudlast_img read more

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10 months agoNorway PM Erna Solberg: I’m no Man Utd insider

first_imgNorway PM Erna Solberg: I’m no Man Utd insiderby Paul Vegas10 months agoSend to a friendShare the loveNorway PM Erna Solberg admits she was wrong to declare Ole Gunnar Solskjaer’s appointment as Manchester United manager before the club had announced it.The appointment was officially announced by United on Wednesday morning – several hours before Solberg’s socia media post.Speaking Thursday at her twice-a-year news conference, Solberg said she had no inside information on Solskjaer’s appointment, adding: “I was seen as an oracle of truth. “I deleted the tweet as I felt I wasn’t the authority to confirm it.” TagsTransfersAbout the authorPaul VegasShare the loveHave your saylast_img

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10 months agoCSKA falling behind Serie A pair in Gabbiadini race

first_imgTagsTransfersAbout the authorPaul VegasShare the loveHave your say CSKA falling behind Serie A pair in Gabbiadini raceby Paul Vegas10 months agoSend to a friendShare the loveCSKA Moscow are struggling to stay in the race for Southampton striker Manolo Gabbiadini.The Mirror says the Italian international has only scored 12 goals in three seasons at St Mary’s following his £15 million move from Napoli.Ralph Hasenhuttl is keen to dump some of his under performing players next month and Gabbiadini who has only scored one this season is among them.He is wanted back in Serie A by Fiorentina and Bologna but they are both only interested in loan moves with an option to buy.Hasenhuttl would rather a permanent deal which CSKA are willing to offer as well pay around £5 million to get their man. last_img read more

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Casino will check hotel rooms even with Do Not Disturb

first_imgATLANTIC CITY, N.J. – One of the world’s largest casino companies will check its guests’ hotel rooms every 24 hours, even if they have a “Do Not Disturb” sign hanging on the doorknob.Caesars Entertainment told The Associated Press Friday it also is considering giving panic buttons to its employees to enable them to quickly summon help if they are in danger or feel threatened. The company will implement the new policy soon at all its properties worldwide, spokeswoman Noel Stevenson said.The company, which owns 47 casinos in five countries, becomes the latest hospitality firm to adopt new room check policies after a gunman broke windows in his Las Vegas hotel room and rained bullets down on an outdoor concert in October, killing 58 people and injuring hundreds before killing himself.“In light of recent tragic events and to further strengthen security, we intend to check rooms with ‘Do Not Disturb’ signs on the door every 24 hours,” Stevenson said.The room checks will be conducted by security guards. The company had proposed having housekeepers do the checks, but changed its mind after opposition from a casino workers’ union.Caesars joins other gambling and hospitality companies who have adopted similar policies requiring guest rooms to be checked periodically, even if a “Do Not Disturb” sign is in use, including Disney, Hilton, MGM Resorts International, Wynn Resorts and Boyd Gaming. The frequency of checks ranges from 12 hours to two days.MGM, which owns the Mandalay Bay casino in Las Vegas where the mass shooting took place, says it requires a room check after two days if a guest has not interacted in person or over the phone with housekeeping or other hotel staff. The company says it also “reserves the right to enter the room if it is deemed appropriate to conduct a welfare check.”Local 54 of the Unite-HERE union had planned to hold a news conference Friday morning on the Atlantic City Boardwalk to oppose Caesars Entertainment’s proposed use of housekeepers to carry out the room checks, but called it off after the company told them it was changing the proposal.“After pressure from workers, Caesars Entertainment has agreed to rescind the room check policy that would have required housekeepers to enter rooms with ‘Do Not Disturb’ sign on them,” the union said in a statement distributed Thursday night. “Additionally, Caesars has informed us that the company is testing safety buttons with the intention of providing them to all housekeepers in the near future. Caesars will also be increasing the security presence on the guest floors.”Union officials declined to comment Friday, and Caesars officials did not address the union’s contention that worker opposition led to a change in the proposal.The union had been concerned not only about the Mandalay Bay shootings in Las Vegas, but also assaults and injuries among Atlantic City casino workers. Those cases include the sexual assault of a hotel worker at Bally’s who was pushed into a room and attacked earlier this month, and a fire at the Tropicana that started when a guest set up an illegal methamphetamine lab in the room. A hotel worker who entered the room after the fire broke out had to be hospitalized.___Follow Wayne Parry at http://twitter.com/WayneParryAClast_img read more

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Germanys Siemens to build new trains for London Underground

first_imgFRANKFURT — German firm Siemens AG has landed a 1.5 billion pound ($1.9 billion) order for new trains for the London Underground’s busy Piccadilly line, which brings 700,000 people in and out of central London every day.The 94 trains from the Siemens Mobility division have fully air-conditioned and walk-through carriages. They will go into service in 2024, replacing trains that date back to the 1970s and have become increasingly unreliable, crowded and expensive to maintain.The company said Tuesday the contract was awarded “with the expectation” Siemens would build single-design trains for all four deep Underground lines: Piccadilly, Bakerloo, Central and Waterloo & City.Siemens has announced plans for a train factory in Goole, East Yorkshire, that will employ 700 people and offer roles for 1,700 suppliers.The Associated Presslast_img read more

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BJP at behest of Delhi police cancelled my rally Kejriwal

first_imgNEW DELHI: In a fresh attack on the BJP, Delhi CM and AAP national convenor Arvind Kejriwal on Saturday alleged that BJP through Delhi police cancelled his rally at Shakur Basti as the party realised that they would lose in this election.Taking a dig at BJP, the Chief Minister said, “Cancel as many rallies of mine you want to, I will go to the people and address them.” He also addressed the issue of full-statehood and explained how the Centre created obstructions to pass the Mohallah Clinic files, CCTV projects and others. Also Read – After eight years, businessman arrested for kidnap & murder”In the last four years, I have worked relentlessly for the development of Delhi. PM Narendra Modi says his chest is of 56 inches, through the work done by the AAP government I have made all Delhiites chest of 59 inches,” he said while addressing a rally at Timarpur, North East Delhi. The Chief Minister added that only the people of Delhi in India can say that the state education system has developed in the last four years, unlike any other state. Also Read – Two brothers held for snatchingsMeanwhile, CM Arvind Kejriwal on Saturday claimed that he was denied permission for a rally in Sant Nagar Chowk here by the Delhi Police at the behest of the BJP. “BJP gets my public rally cancelled today thro police. Police deny permission. How many BJP rallies were denied permission by police in Delhi in last 5 yrs? ” Kejriwal said in a tweet. He said the people will teach the BJP a lesson for not fulfilling its promise of granting full statehood to Delhi. Police, however, said the permission for the proposed public meeting was not given as the site witnesses heavy traffic snarls and huge footfall of people on weekends due to the weekly market. They said they had proposed an alternative venue which was 150 metres away from the site. “Busy intersection of Sant Nagar Chowk was not found fit for a proposed public meeting of 2000, with around 1000 seats and pandal, due to heavy traffic and a weekly market. This was conveyed on 20-03-2018,” tweeted DCP Outer Delhi, Seju P Kuruvilla.last_img read more

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